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Laboratory Corporation of America Scientist I-Assay Development and Bioinformatics - San Francisco, CA in South San Francisco, California

Summary

The Monogram division of Labcorp, which is focused on high complexity cell-based assay development, has an exciting opportunity for a Scientist I-Assay Development and Bioinformatics to join its R&D Diagnostics Development Team. The selected candidate will plan and execute proof of concept experiments and assess the time and resources required for development. Along with other team members, he/she will plan and execute experiments, critically analyze the data and interpret the results. The ideal candidate will have extensive knowledge of cell culture techniques and molecular biology as well as a proven track record in development of novel nucleic acid detection assays.

Experience with development of bioinformatics tools and algorithms for analysis of genomic data, in particular NGS and/or microarray data, is preferred. Understanding the fundamentals of sampling statistics and low frequency variant detection is a plus.

This is an exciting opportunity to be part of a dynamic R&D team and have the opportunity to participate in novel technology development.

Responsibilities:

  • Designs model systems for proof-of-concept studies

  • Develops NGS methods and performs data analysis/interpretation

  • Develops target enrichment approaches utilizing multiplex PCR and/or captures methods

  • Designs and executes appropriate analytical verification studies

  • Performs data analysis with graphical representations of findings using appropriate software (R, Excel, JMP)

  • Develops sequence analysis pipeline for NGS data analysis for various platforms including PacBio and Illumina

  • Documents all work in the form of laboratory notebook, study reports, summary reports and presentations

  • Presents data clearly and concisely at departmental meetings and project meetings

  • Participates and presents findings at conferences

  • Publishes scientifically relevant data in peer reviewed journals

  • Participates in the development of patent applications, if applicable

Requirements

Requires Ph.D. with 0 - 3 year's work experience relevant to position or relevant PostDoc (or equivalent experience). Non-Ph.D. must have demonstrated the ability to ably and independently perform all elements of the job, have exceptional capabilities in own field of expertise and the potential for creativity and external collaboration. This is a Ph.D. entry level position.

Requirements, Strongly preferred

  • PhD in Molecular Biology, Genetics or related field

  • Experience with creation and optimization of NGS-based assays

  • Experience with targeted NGS pipeline development

  • Strong background in experimental design and assay optimization

  • Experience with immunology, virology, and/or novel disease assay development

  • Experience and knowledge of bioinformatics, biostatistics, machine learning algorithms, and software development tools

  • Experience with NGS data analysis

  • Expertise in R, Perl, Python and SQL

  • Experience with UNIX/Linux and Windows Operating Systems

  • Experience and deep understanding of database structures and platforms (particularly ORACLE and MYSQL)

Shift

1

Schedule

Monday-Friday 9am-6pm

As an EOE/AA employer, the organization will not discriminate in its employment practices due to an applicant's race, color, religion, sex, national origin, sexual orientation, gender identity, disability or veteran status.

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