Laboratory Corporation of America Scientist I-Assay Development and Bioinformatics - San Francisco, CA in South San Francisco, California
The Monogram division of Labcorp, which is focused on high complexity cell-based assay development, has an exciting opportunity for a Scientist I-Assay Development and Bioinformatics to join its R&D Diagnostics Development Team. The selected candidate will plan and execute proof of concept experiments and assess the time and resources required for development. Along with other team members, he/she will plan and execute experiments, critically analyze the data and interpret the results. The ideal candidate will have extensive knowledge of cell culture techniques and molecular biology as well as a proven track record in development of novel nucleic acid detection assays.
Experience with development of bioinformatics tools and algorithms for analysis of genomic data, in particular NGS and/or microarray data, is preferred. Understanding the fundamentals of sampling statistics and low frequency variant detection is a plus.
This is an exciting opportunity to be part of a dynamic R&D team and have the opportunity to participate in novel technology development.
Designs model systems for proof-of-concept studies
Develops NGS methods and performs data analysis/interpretation
Develops target enrichment approaches utilizing multiplex PCR and/or captures methods
Designs and executes appropriate analytical verification studies
Performs data analysis with graphical representations of findings using appropriate software (R, Excel, JMP)
Develops sequence analysis pipeline for NGS data analysis for various platforms including PacBio and Illumina
Documents all work in the form of laboratory notebook, study reports, summary reports and presentations
Presents data clearly and concisely at departmental meetings and project meetings
Participates and presents findings at conferences
Publishes scientifically relevant data in peer reviewed journals
Participates in the development of patent applications, if applicable
Requires Ph.D. with 0 - 3 year's work experience relevant to position or relevant PostDoc (or equivalent experience). Non-Ph.D. must have demonstrated the ability to ably and independently perform all elements of the job, have exceptional capabilities in own field of expertise and the potential for creativity and external collaboration. This is a Ph.D. entry level position.
Requirements, Strongly preferred
PhD in Molecular Biology, Genetics or related field
Experience with creation and optimization of NGS-based assays
Experience with targeted NGS pipeline development
Strong background in experimental design and assay optimization
Experience with immunology, virology, and/or novel disease assay development
Experience and knowledge of bioinformatics, biostatistics, machine learning algorithms, and software development tools
Experience with NGS data analysis
Expertise in R, Perl, Python and SQL
Experience with UNIX/Linux and Windows Operating Systems
Experience and deep understanding of database structures and platforms (particularly ORACLE and MYSQL)
As an EOE/AA employer, the organization will not discriminate in its employment practices due to an applicant's race, color, religion, sex, national origin, sexual orientation, gender identity, disability or veteran status.