Laboratory Corporation of America Senior Scientist - NGS Assay Development in San Diego, California

Sequenom, a wholly-owned subsidiary of Laboratory Corporation of America Holdings (LabCorp), is a CAP accredited and CLIA-certified molecular diagnostics laboratory, dedicated to the development and commercialization of laboratory-developed tests (LDTs) for prenatal conditions, cancer, and other diseases.

As a member of the R&D Diagnostic Development team, the Senior Scientist will lead laboratory initiatives with responsibilities including the planning, execution, and analysis of assay development projects with a particular focus on innovative and challenging programs like liquid biopsy. The ideal candidate will have extensive knowledge of molecular biology and biochemistry as well as a proven track record in development of novel nucleic acid detection assays. Experience with the analysis of complex genomic data, in particular NGS and/or microarray data, is preferred. Understanding of the biology of cancer as well as the challenges and limitations of low frequency variant detection is a plus. This is an exciting opportunity to be part of a dynamic R&D team and have the opportunity to participate in novel technology development.

Responsibilities:

  • Design cutting-edge assays and experiments, execute experimental protocols, and analyze data for review

  • Contribute to the team focusing on the development of liquid biopsy and other molecular diagnostic assays

  • Develop next generation sequencing assays and perform data analysis/interpretation

  • Conceive and design model systems for proof-of-concept studies

  • Design and execute appropriate analytical verification studies

  • Perform data analysis with graphical representations of findings using appropriate software (R, Excel, JMP)

  • Present data clearly and concisely at departmental meetings and project meetings

  • Develop target enrichment approaches utilizing multiplex PCR and/or capture methods

  • Participate and present findings at conferences

  • Publish scientifically relevant data in peer reviewed journals

  • Participate in the development of patent applications, if applicable

  • Independently and/or collaboratively conceive, initiate, and apply for the acceptance of new projects

  • Document all work in the form of laboratory notebook, study reports, summary reports and presentations

Requirements

  • PhD in Molecular Biology, Genetics or related field and 5-10 years' industrial experience in an applied research and/or development environment

  • Experience with optimization of next generation sequencing-based assays

  • Experience with targeted NGS enrichment technologies

  • Experience with oncology, prenatal, and/or infectious disease assay development preferred.

  • Strong background in experimental design and assay optimization.

  • Strong background in data analysis using statistical software packages including R or JMP

  • Project and resource management experience a plus

Shift

1

Schedule

1st Shift-Monday-Friday

As an EOE/AA employer, the organization will not discriminate in its employment practices due to an applicant's race, color, religion, sex, national origin, sexual orientation, gender identity, disability or veteran status.